Figure 5. Spinal spreading potentiation during right hindpaw ischaemia in wild‐type and nNOS knockout mice.

A, experimental method. B, spinal responses elicited by left hindpaw stimulation in wild‐type (nNOS+/+) mice before and after the onset of ischaemia in the right hindpaw. Original and pseudocolour images in ΔF/F ₀ of the spinal cord are shown. C, spinal responses elicited by left hindpaw stimulation in knockout (nNOS−/−) mice before and after the onset of ischaemia in the right hindpaw. Original and pseudocolour images in ΔF/F ₀ are shown. D, relative amplitudes of the spinal responses normalized by those recorded before the onset of ischaemia. [Color figure can be viewed at http://wileyonlinelibrary.com]