Table 5.
Ten most reported serious hepatic ADRs for the HMs (single suspect) listed in Table 4 (non-specified HMs = Group NOS).
| Herbal medicine | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Reported reaction | Group nos | Valeriana officinalis | Cimicifuga racemosa | Camellia sinensis | Glycine max | Serenoa repens | Hypericum perforatum | Chelidonium majus | Hintonia latiflora | Aloe vera | Aristolochia fontanesii | Arctostaphylos uva-ursi | Petasites hybridus | Viscum album | Total |
| 1.Drug-induced liver injury | 21 | 10 | 1 | 2 | 1 | 35 | |||||||||
| 2.Jaundice | 16 | 3 | 2 | 1 | 2 | 1 | 2 | 1 | 2 | 30 | |||||
| 3.Acute hepatic failure | 21 | 1 | 1 | 23 | |||||||||||
| 3.Hepatic function abnormal | 22 | 1 | 23 | ||||||||||||
| 4.Hepatitis | 13 | 2 | 3 | 1 | 3 | 22 | |||||||||
| 5.Liver disorder | 18 | 1 | 19 | ||||||||||||
| 6.Liver injury | 9 | 4 | 1 | 1 | 15 | ||||||||||
| 7.Hepatitis cholestatic | 8 | 1 | 2 | 1 | 12 | ||||||||||
| 8.Hepatitis toxic | 4 | 2 | 1 | 1 | 1 | 1 | 10 | ||||||||
| 9.Cholestasis | 2 | 7 | 9 | ||||||||||||
| 10.Hepatitis acute | 3 | 2 | 2 | 1 | 8 | ||||||||||
| Total | 135 | 12 | 11 | 11 | 8 | 4 | 4 | 4 | 4 | 3 | 3 | 3 | 2 | 2 | 206 |
ADRs, adverse drug reactions; HM, herbal medicine.