Table 5.
Cysteine proteases IC50 values in live parasites
| Inhibitor | IC50,DPAP3 (nm) | IC50,DPAP1 (nm) | IC50,FP1 (nm) | IC50,FP2/3 (nm) |
|---|---|---|---|---|
| hPro‐hPhe‐VS | 160 ± 50 | 80 ± 7 | 350 ± 80 | 3300 ± 1000 |
| Pro‐hPhe‐VS | > 10 000 | 275 ± 25 | ~ 10 000 | > 10 000 |
| hPro‐nLeu(o‐Bzl)‐VS | 900 ± 100 | 62 ± 7 | 300 ± 100 | 1900 ± 500 |
| Tyr(NO2)‐hPhe‐VS | 190 ± 20 | > 10 000 | > 10 000 | > 10 000 |
| Tyr(NO2)‐nLeu(o‐Bzl)‐VS | 730 ± 170 | > 10 000 | > 10 000 | > 10 000 |
| L‐Trp‐hPG‐VS | 1.4 ± 0.4 | > 10 000 | > 10 000 | > 10 000 |
| L‐Trp‐hPhe‐VS | 130 ± 60 | > 10 000 | > 10 000 | > 10 000 |
| L‐Trp‐nLeu(o‐Bzl)‐VS | 760 ± 150 | ~ 10 000 | ~ 10 000 | ~ 10 000 |
| D‐Trp‐hPhe‐VS | 6800 ± 1600 | > 10 000 | > 10 000 | > 10 000 |
| D‐Trp‐nLeu(o‐Bzl)‐VS | 2700 ± 1600 | > 10 000 | > 10 000 | > 10 000 |
Technical triplicates were performed for each compound. Standard errors are shown.