Table 3.

Multivariate linear regression of SMO, GLI‐1, p53 and p16 correlated with multiple parameters

	SMO		GLI‐1		p53		p16
	t‐value	P‐value	t‐value	P‐value	t‐value	P‐value	t‐value	P‐value
pT	−0.376	0.708	−1.970	0.053	−0.301	0.765	0.701	0.486
pN	0.795	0.430	1.249	0.216	−0.420	0.676	0.328	0.744
Grading	−0.391	0.697	1.024	0.309	2.969	0.004	−0.536	0.594
SMO	NA	NA	2.810	0.007	1.084	0.282	−1.798	0.077
GLI‐1	2.810	0.007	NA	NA	−0.494	0.623	1.316	0.193
p53	1.084	0.282	−0.494	0.623	NA	NA	0.304	0.762
p16	−1.798	0.077	1.316	0.193	0.304	0.762	NA	NA

Significant associations are depicted in bold type. pT, tumour–node–metastasis (TNM) classification of malignant tumours T stage; pN, TNM classification of malignant tumours N stage; GLI‐1, GLI family zinc finger 1; SMO, smoothened, frizzled class receptor; p53, tumour protein p53; NA, not applicable; P16, cyclin‐dependent kinase inhibitor 2A, multiple tumour suppressor 1.