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. 2019 Jun 17;17(8):1229–1239. doi: 10.1111/jth.14487

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© 2019 The Authors. Journal of Thrombosis and Haemostasis published by Wiley Periodicals, Inc. on behalf of International Society on Thrombosis and Haemostasis

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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The factor Va A3 domain interacts with the serine protease and EGF domains of factor Xa. A zoomed‐in region of the human ternary model by Shim et al. is shown38; the insert outlines the specific region depicted. All highlighted residues (pink spheres) in FVa, spanning from Asn1547 to Lys1725 (specified in Table S2), are located close to FXa and may be directly involved in the formation of the prothrombinase complex. FVa (teal) and FXa (orange cartoon) are indicated; prothrombin has been removed for clarity. See Movie S4 for a 3D overview. Abbreviations: FVa, factor Va; FXa, factor Xa