Table 4.
Results of longitudinal analysis
| Variable | Original data set | Imputed data sets | ||
|---|---|---|---|---|
| Estimate [95%CI] | P‐value | Estimate [95%CI] | P‐value | |
| −0.172 [−1.341; 0.996] | 0.766 | 0.258 [−0.570; 1.084] | 0.542 | |
| Age | 0.032 [−0.020; 0.084] | 0.213 | 0.021 [−0.016; 0.058] | 0.258 |
| Route of administration | 0.322 [−0.848; 1.492] | 0.587 | 0.230 [−0.769; 1.229] | 0.652 |
| Dose | 0.387 [0.247; 0.527] | <0.001 | 0.296 [0.167; 0.425] | <0.001 |
| ALT | 0.006 [0.000; 0.012] | 0.040 | 0.004 [−0.003; 0.010] | 0.266 |
| AST | 0.004 [−0.013; 0.021] | 0.648 | 0.005 [−0.013; 0.023] | 0.575 |
| ALP | −0.001 [−0.008; 0.007] | 0.870 | 0.001 [−0.006; 0.007] | 0.815 |
| γ‐GT | −0.000 [−0.003; 0.003] | 0.939 | −0.000 [−0.003; 0.002] | 0.803 |
| Bilirubin | −0.009 [−0.035; 0.016] | 0.467 | −0.006 [−0.025; 0.012] | 0.506 |
| CRP | 0.001 [−0.004; 0.006] | 0.597 | −0.001 [−0.005; 0.004] | 0.691 |