Table 4.

Ratios of Risankizumab C_max and AUC in Healthy Japanese and Chinese Subjects Relative to White Subjects

Regimens		Exposure Ratiosa (Not Accounting for Body Weight)		Exposure Ratiosa (Adjusted for Body Weight)
Test vs Reference	Pharmacokinetic Parameter	Point Estimate	90%CI	Point Estimate	90%CI
Japanese vs white	Cmax	1.32	1.03–1.69	0.84	0.61–1.14
	AUC∞	1.31	1.10–1.56	1.02	0.81–1.30
Chinese vs white	Cmax	1.35	1.06–1.70	1.08	0.86–1.35
	AUC∞	1.22	1.03–1.45	1.05	0.88–1.25

AUC_∞ indicates area under the plasma concentration‐time curve from time 0 to infinity; C_max, maximum plasma concentration.

^aRatio was calculated by exponentiation of the difference between the logarithms of the least‐squares means calculated based on 1‐way ANOVA.