Figure 1.

Individuals with obesity and older individuals experience an increase in lipid deposition in visceral and ectopic fat depots. This may affect metabolism in key organs including adipose tissue, liver, and skeletal muscle, which may result in the development of muscle insulin resistance and a decrease in muscle mass. Patients often enter a vicious cycle in which decreased activity levels and increased incidence of falls lead to more muscle loss, a deterioration in quality of life, and premature death. Exercise (E) is an effective strategy to reduce obesity and improve lipid metabolism. It will ameliorate muscle mass loss and the development of insulin resistance, and it will reduce the incidence of falls and improve quality of life