Table 1.

Burden of haemophilia

Burden	Cause
Joint damage	Can result in chronic pain, disability and joint deformity at an early age 1, 54, 55
Poor health‐related quality of life	Closely linked to the extent of joint damage 54
Functional impairment	More likely to suffer from arthropathy/arthritis, more likely to require knee/hip replacement compared with the general population.1, 56 Poor mobility, self‐care issues, and inability to perform usual daily activities 57, 58
Social isolation	Inability to participate in social or sporting activities 59
Pain	Higher pain levels and functional impairment associated with anxiety, depression and unemployment.60, 61 Pain/discomfort is an area where most individuals report experiencing ‘extreme’ issues.54 Individuals may experience anger and frustration due to the pain, inconvenience and erratic nature of bleeds 62
Psychological	Anxiety/depression are the areas where most individuals report experiencing ‘extreme’ issues 54
Personal productivity	Adverse impact on educational achievement and work productivity due to absence and difficulties due to functional impairments and pain 57, 63, 64