Figure 1.

Models of clonal evolution of AML over time. Each circle corresponds to an individual cell, multiple identical cells correspond to cell clones, each defined by harboring the identical set of mutations. Cells without symbols refer to wild type cells without somatic mutations. Somatic mutations are represented by different symbols, colored based on their stability: orange (stable mutation), blue (diagnosis‐specific mutation), and red (relapse‐specific mutation). Cells of the relapse originating clone are highlighted in red. (A) Linear evolution describes the sequential acquisition of mutations. The relapse originating cell is part of the major clone at diagnosis. (B) Branching evolution describes the eradication of the major clone and subsequent outgrowth of a secondary clone. The relapse originating cell is part of a subclone at diagnosis. AML, acute myeloid leukemia