Table 2. Primary information for MTHFR polymorphisms.

Genotyped SNPs	rs3753584 T>C	rs4846048 A>G	rs4845882 G>A	rs1801133 G>A	rs9651118 T>C
Chromosome	1	1	1	1	1
Location (NCBI Build 37)	11864586	11846252	11843167	11856378	11862214
Function	NearGene-5	Intron	Intron	Missense	Intron
Regulome DB scores (http://www.regulomedb.org/)	4	3a	1f	4	5
Transcription factor binding site (http://snpinfo.niehs.nih.gov/snpinfo/snpfunc.htm)	Y	-	-	-	Y
MiRNA (miRanda)	-	Y	-	-	-
MAF1 for Chinese in database	0.093	0.105	0.198	0.439	0.382
MAF in our controls (n=923)	0.111	0.095	0.216	0.354	0.378
P-value for HWE2 test in our controls	0.814	0.029	0.437	0.074	0.021
Genotyping method	SNPscan	SNPscan	SNPscan	SNPscan	SNPscan
% Genotyping value	99.27%	99.27%	99.27%	99.27%	99.27%

¹MAF, minor allele frequency.

²HWE.