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. 2019 Oct 17;13:1179069519883580. doi: 10.1177/1179069519883580

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© The Author(s) 2019

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — To analyze the behavior of leptin-deficient (ob/ob) mice, the open field (OF) test as well as the Morris water maze (MWM) test was used. (A) In the OF, ob/ob mice covered significantly shorter distances compared with wild-type (wt) mice. (B) In the OF, the ob/ob mice displayed significantly reduced velocity compared with the wt mice. (C) The ob/ob mice displayed a significantly reduced swimming speed in the MWM. (D) Concerning the time to reach the platform, ob/ob mice showed overall comparable results to their controls. Only on day 5, the ob/ob mice even performed better than the control mice. (E) In the MWM, both groups of mice did not differ in their accuracy to find the platform. (F) In the probe trial, the ob/ob mice showed no significant differences regarding the time to reach the platform position. (G) In the probe trial, the leptin-deficient (ob/ob) mice nearly spent the same time in the platform quadrant as the mice of the control group (wt).