Table 2.
Partition coefficients (K) of compound 1 in two‐phase solvent systems
| Solvent system | Ratio (v/v) | K a |
|---|---|---|
| n‐hex/EtOAc/MeOH/water | 9:1:9:1 | 0.00 |
| n‐hex/EtOAc/MeOH/water | 8:2:8:2 | 0.01 |
| n‐hex/EtOAc/MeOH/water | 7:3:7:3 | 0.00 |
| n‐hex/EtOAc/MeOH/water | 7:3:6:4 | 0.01 |
| n‐hex/EtOAc/MeOH/water | 6:4:6:4 | 0.01 |
| n‐hex/EtOAc/MeOH/water | 7:3:5:5 | 0.01 |
| n‐hex/EtOAc/MeOH/water | 5:5:5:5 | 0.05 |
| n‐hex/EtOAc/MeOH/water | 3:7:5:5 | 0.26 |
| n‐hex/EtOAc/MeOH/water | 4:6:4:6 | 0.23 |
| n‐hex/EtOAc/MeOH/water | 3:7:4:6 | 0.49 |
| n‐hex/EtOAc/MeOH/water | 4:10:4:10 | 1.21 |
| n‐hex/EtOAc/MeOH/water | 2:8:2:8 | 2.98 |
| n‐hex/EtOAc/MeOH/water | 1:9:1:9 | 7.18 |
| n‐hex/EtOAc/MeOH/water | 0:10:0:10 | 13.65 |
| EtOAc/DME/water | 2:1:1 | 5.69 |
| MTBE/DME/water | 1:2:1 | 0.92 |
| MTBE/DME/water | 2:1:2 | 1.25 |
| MTBE/DME/water | 2:2:1 | 0.77 |
| MTBE/DME/water | 2:2:2 | 1.04 |
| n‐hep/DCM/ACN | 10:3:7 | 0.01 |
| n‐hex/EtOAc/MeOH/water/DME | 7:3:6:4:2 | 0.01 |
| MTBE/DME/Ace/water | 4:1:1:4 | 1.28 |
| n‐hex/ACN | 1:1 | 0.00 |
| MTBE/EtOAc/water | 2:1:2 | 4.67 |
| MTBE/EtOH/water | 2:1:2 | 4.12 |
| MTBE/MeOH/water | 2:1:2 | 2.19 |
| MTBE/n‐prop/water | 2:1:2 | 18.99 |
| MTBE/2‐prop/water | 2:1:2 | 10.19 |
| MTBE/n‐BuOH/water | 2:1:2 | 45.42 |
a
Calculation based on the analysis results using the developed HPLC method at 230 nm
2‐prop, 2‐propanol; Ace, acetone; DME, dimethoxyethane; EtOH, ethanol absolute; MTBE, methyl tert‐butyl ether; n‐BuOH, n‐butanol absolute; n‐hep, n‐heptane; n‐prop, n‐propanol