Figure 2.

In amyotrophic lateral sclerosis (ALS), the average co‐modulation is significantly increased in the δ, θ and γ frequency bands. Notice the increase of amplitude envelope correlation (AEC) in the central and posterior regions (δ‐, θ‐ and γ_l‐band) and frontal regions (δ‐ and γ_l‐band). Statistical difference between healthy controls (n = 47) and ALS patients (n = 74) was assessed in the six defined frequency bands using empirical Bayesian inference (EBI). False discovery rate (FDR) was set to 10%, yielding an estimated statistical power of 1–β = .93 and posterior probability of P ₁ = .71 (across all frequency bands). AUC, area under the receiver operating characteristic curve. Frequency bands: δ (2–4 Hz), θ (5–7 Hz), α (8–13 Hz), β (14–30 Hz) and γ (γ_l: 31–47 Hz, γ_h: 53–97 Hz) [Color figure can be viewed at http://wileyonlinelibrary.com]