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. 2019 May 28;70(4):1377–1391. doi: 10.1002/hep.30651

Figure 7.

Figure 7

Assessing impact antifibrotic therapies in fibrosis‐induced rat liver slices. (A‐C) mRNA levels of Col1A1, αSMA, and TIMP1 in rPCLS at t = 0 and after 24‐hour rest + 72‐hour culture ± fib stim ± nintedanib, OCA, and losartan (96‐hour total culture). Data are mean ± SEM in n = 5 different livers. *P < 0.05; **P < 0.01; ***P < 0.001; ***P < 0.0001. (D) Average media albumin (ng/mL) levels in bioreactor‐cultured rPCLSs after 24‐hour rest and then 24‐ to 72‐hour culture ± fib stim (TGFβ1/PDGFββ) ± Alk5i, nintedanib, OCA, and losartan (48‐ and 96‐hour total culture). Abbreviations: Cont, control; fib stim, fibrotic stimulation; Nint, nintedanib; Veh, vehicle.