Table 3.

Linear regression analyses for factors associated with the ratio of periventricular hyperintensities and deep white matter hyperintensities volume to intracranial volumes in mild cognitive impairment patients

	Ratio of PVH volume			Ratio of DWMH volume
Independent variable	B	β	P‐value	B	β	P‐value
Sex	0.143	0.119	0.775	−0.129	−0.231	0.617
Age	0.000	−0.005	0.982	−0.003	−0.065	0.791
AST	0.016	0.338	0.461	0.01	0.451	0.377
ALT	−0.014	−0.209	0.65	−0.02	−0.648	0.219
T‐Cho	−0.003	−0.182	0.743	−0.009	−1.037	0.112
LDL‐Cho	−0.005	−0.236	0.574	0.007	0.664	0.169
BUN	0.000	−0.003	0.992	−0.017	−0.272	0.415
Cr	−1.957	−0.858	0.276	0.85	0.797	0.355
eGFR	−0.03	−0.729	0.134	0.000	0.000	0.999
Glu	−0.002	−0.049	0.887	0.005	0.323	0.402
HbA1c	−0.119	−0.089	0.832	−0.009	−0.014	0.975
VitB12	0.000	−0.18	0.38	0.000	−0.094	0.673
CysC	2.807	1.095	0.016*	0.495	0.413	0.349
25(OH)VitD	−0.013	−0.264	0.238	0.008	0.37	0.143
Homocysteine	−0.05	−0.307	0.378	−0.031	−0.414	0.286
Hypertension	0.83	0.733	0.302	0.09	0.169	0.825
Diabetes mellitus	0.33	0.219	0.588	−0.412	−0.582	0.21
Hypercholesterolemia	−0.401	−0.354	0.351	−0.02	−0.039	0.925
Coronary artery disease	−0.309	−0.125	0.567	0.154	0.134	0.58
Antidiabetic medication	−0.108	−0.044	0.875	0.626	0.543	0.102
Statin	−0.07	−0.055	0.853	0.105	0.177	0.593
Antithrombotics	0.528	0.258	0.297	0.382	0.4	0.155
Antihypertensives	−0.738	−0.653	0.381	−0.2	−0.379	0.641

25(OH)VitD, 25‐hydroxyvitamin D; ALT, alanine aminotransferase; AST, aspartate transaminase; BUN, blood urea nitrogen; Cr, creatinine; CysC, cystatin C; DWMH, deep white matter hyperintensities; FAB, Frontal Assessment Battery; eGFR, estimated glomerular filtration rate; Glu, glucose; HbA1c, hemoglobin A1c; LDL‐Cho, low‐density lipoprotein cholesterol; PVH, periventricular hyperintensities; T‐Cho, total cholesterol; VitB12, vitamin B₁₂.

^* P < 0.05, significant correlation between ratio of PVH or DWMH volume to ICV.