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. 2019 Nov 1;10:2582. doi: 10.3389/fimmu.2019.02582

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Copyright © 2019 Dahora, Jin, Spreng, Feely, Mathura, Seaton, Zhang, Hill, Jones, Alam, Dennison, Pollard and Tomaras.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ViBIOT-specific total IgA magnitude, fold change, and avidity higher in protected individuals of both vaccine groups. ViBIOT-specific IgA magnitude (A) and fold change (B) by vaccine group over time. ViBIOT-specific IgA magnitude (C) and fold change (D) by diagnosed/protected outcome at day of challenge. ViBIOT IgA avidity index (E) by diagnosed/protected outcome at day of challenge. Diagnosed and protected individuals are represented by open and closed circles, respectively. Data points are representative of n = 2 independent experiments (each with n = 2 technical replicates). n.s indicates non-significant FDR-corrected p values.