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. 2019 Nov 12;38:465. doi: 10.1186/s13046-019-1428-0

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Effect of RP11-468E2.5 on the mRNA expression of JAK/STAT signaling pathway- and apoptosis-related genes in HCT116 and SW480 cells. a RP11-468E2.5 expression and mRNA expression of the JAK/STAT signaling pathway-related genes and apoptosis-related genes determined by RT-qPCR in HCT116 cells. b RP11-468E2.5 expression and mRNA expression of the JAK/STAT signaling pathway- and apoptosis-related genes determined by RT-qPCR in SW480 cells; RT-qPCR, reverse transcription quantitative polymerase chain reaction; NC, negative control; JAK1, janus kinase 1; STAT3, signal transducer and activator of transcription-3; STAT5, signal transducer and activator of transcription-5; STAT6, signal transducer and activator of transcription-6; Bcl-2, B-cell leukemia/lymphoma 2; CCND1, Cyclin D1. * p < 0.05, compared with the blank group