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. 2019 Nov 12;38:463. doi: 10.1186/s13046-019-1466-7

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Model depicting that PES1 interacted with BRD4 and contributed to the BET inhibitor resistance via increasing the expression levels of c-Myc in pancreatic cancer. CDK5 phosphorylated and stabilized PES1. Dinaciclib was proved to down-regulate PES1 and overcome the JQ1 resistance in pancreatic cancer cells