Table 1.
Demographic and Laboratory Parameters of the Different Studied Groups
| Variables | Group I | Group II (Cirrhosis) | Group III (Control) | (P-value) |
|---|---|---|---|---|
| mean ± SE | (HCC) (n = 20) | (n = 20) | (n = 20) | |
| Gender | ||||
| Male n (%) | 16 (80) | 13 (65) | 10 (50) | |
| Female n (%) | 4 (20) | 7 (35) | 10 (50) | 0.094 |
| Age (years) | 56.95± 1.73 | 56.50± 2.1 | 52.35± 1.4 | 0.137 |
| AST (U/L) | 78.25± 15.14 a | 77.45± 10.5 a | 31± 1.6 | 0.003 |
| ALT (U/L) | 86.07 ± 17.6 a | 80.25± 12.9 a | 22.73± 1.5 | 0.001 |
| ALB (g/dl) | 3.40± 0.1a | 3.77± 0.1a | 4.25± 0.1 | <0.001 |
| T- Bil (mg/dl) | 1.42± 0.2 a | 1±0.1 a | 0.86± 0.05 | 0.03 |
| INR | 1.15± 0.08 a | 1.14± 0.03 a | 0.94± 0.02 | 0.01 |
| PLT (×103/μL) | 132± 13.7 a | 152.70± 20.96 a | 299.35± 19.7 | <0.001 |
| AFP (ng/ml) | 463.3± 193.28 a,b | 25.3±5.9 a,b | 9.92± 0.73 | 0.008 |
| MiRNA-122 (RQ) | 0.103± 0.06 a,b | 2.98± 3.32 a | 1.96± 0.43 | 0.001 |
| MiRNA-224 (RQ) | 5.4± 1.3 a,b | 1.89± 0.6 a | 1.02± 0.3 | 0.001 |
a, Significantly differs from control group; b, Significantly differs from cirrhotic group; SE, standard error; AST, aspartate aminotransferase; ALT, alanine aminotransferase; ALB, Albumin; T. Bil, total bilirubin; INR, international normalized ratio; AFP, alpha-fetoprotein; miRNA, micro RNA; RQ, Relative quantity.