Table 3.
Univariate and multivariate analysis and predictors of MACCEs within 1 year after PCI
| Variable | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| OR | 95% CI | P value | OR | 95% CI | P value | |
| TyG index grouping | ||||||
| Q1 | 1 | 1 | ||||
| Q2 | 1.096 | 0.778–1.545 | 0.600 | 1.117 | 0.668–1.843 | 0.587 |
| Q3 | 1.542 | 1.083–2.194 | 0.016 | 1.356 | 0.852–2.160 | 0.199 |
| Q4 | 1.809 | 1.263–2.590 | 0.001 | 1.529 | 1.001–2.061 | 0.003 |
| Age, years | 1.021 | 1.011–1.032 | < 0.001 | 1.011 | 0.992–1.031 | 0.233 |
| Male | 0.922 | 0.676–1.256 | 0.605 | |||
| BMI, kg/m2 | 1.005 | 0.950–1.043 | 0.460 | |||
| SBP, mmHg | 1.001 | 0.994–1.006 | 0.839 | |||
| DBP, mmHg | 0.990 | 0.981–0.999 | 0.029 | 0.993 | 0.982–1.005 | 0.258 |
| Heart rate, bpm | 0.999 | 0.991–1.008 | 0.905 | |||
| Killip class > 1 | 2.188 | 1.667–2.874 | < 0.001 | 1.722 | 1.185–2.471 | 0.002 |
| Smoker | 1.347 | 1.047–1.733 | 0.020 | 1.191 | 0.858–1.653 | 0.297 |
| Hypertension | 1.631 | 1.250–2.127 | < 0.001 | |||
| Diabetes mellitus | 1.672 | 1.261–2.216 | < 0.001 | |||
| Anemia | 1.351 | 0.940–1.941 | < 0.001 | 1.282 | 0.995–1.563 | 0.024 |
| Previous AMI | 1.151 | 0.499–2.655 | 0.742 | |||
| Atrial fibrillation | 0.864 | 0.463–1.611 | 0.645 | |||
| Biochemical indicators | ||||||
| NT-proBNP, pg/mL (IQR) | 1.057 | 0.909–1.158 | 0.770 | |||
| Cardiac troponin I, ng/ml | 1.018 | 0.830–1.257 | 0.571 | |||
| hs-CRP, mg/L (IQR) | 1.026 | 0.975–1.074 | 0.302 | |||
| White blood cells, 109/L | 1.037 | 1.001–1.075 | 0.047 | 1.038 | 0.988–1.091 | 0.141 |
| Neutrophil ratio | 0.998 | 0.988–1.008 | 0.680 | |||
| Platelet, 109/L | 1.002 | 1.000–1.004 | 0.025 | 1.002 | 0.999–1.004 | 0.285 |
| Albumin, g/L | 0.971 | 0.947–0.996 | 0.023 | 0.963 | 0.928–1.000 | 0.050 |
| Measured HbA1c, % | 1.173 | 1.042–1.321 | 0.005 | |||
| FPG, mmol/L | 1.040 | 1.010–1.072 | 0.009 | |||
| TC, mmol/L | 1.015 | 0.916–1.124 | 0.781 | |||
| Triglycerides, mmol/L | 1.021 | 0.909–1.131 | 0.503 | |||
| HDL-C, mmol/L | 0.813 | 0.494–1.339 | 0.813 | |||
| LDL-C, mmol/L | 0.938 | 0.806–1.092 | 0.412 | |||
| Uric acid, umol/L | 1.002 | 1.001–1.003 | 0.002 | 1.002 | 1.000–1.004 | 0.013 |
| eGFR, mL/min | 0.995 | 0.991–0.999 | 0.009 | 0.999 | 0.993–1.005 | 0.751 |
| Coronary angiography | ||||||
| GPIIb/IIIa antagonists | 0.910 | 0.703–1.176 | 0.470 | |||
| Anticoagulation | 1.406 | 0.773–2.557 | 0.264 | |||
| Lesion vessels | 1.163 | 1.071–1.263 | < 0.001 | 1.092 | 0.960–1.243 | 0.180 |
| Three-vessel disease | 1.394 | 1.084–1.793 | 0.010 | 1.244 | 0.830–1.865 | 0.289 |
| Number of stents | 1.575 | 1.220–2.032 | < 0.001 | 1.709 | 1.229–2.375 | 0.001 |
| Gensini score | 1.008 | 1.002–1.017 | 0.022 | 1.002 | 0.993–1.010 | 0.366 |
| LVEF | 0.303 | 0.099–0.931 | 0.037 | 0.121 | 0.029–0.057 | 0.004 |
| Medications use at discharge | ||||||
| Aspirin | 0.687 | 0.368–1.282 | 0.238 | |||
| Clopidogrel/ticagrelor | 0.782 | 0.276–2.213 | 0.643 | |||
| Statin | 1.776 | 0.834–3.781 | 0.136 | |||
| Beta blockers | 0.979 | 0.716–1.339 | 0.895 | |||
| ACEI/ARB | 1.208 | 0.917–1.590 | 0.179 | |||
Co-linearity analysis showed that hypertension, diabetes, HbA1c, FPG and TyG index had high co-linearity. Therefore, hypertension, diabetes, HbA1c and FPG weren’t included in multivariate model
BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, AMI acute myocardial infarction, IQR interquartile range, hs-CRP hypersensitive C-reactive protein, TC total cholesterol, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, SCr Serum creatinine concentration, eGFR estimated glomerular filtration rate, LVEF left ventricular ejection fraction, ACEI angiotensin converting enzyme inhibitor, ARB angiotensin receptor blocker