Table 2.
SNPs showing significant p-value before FDR correction
| SNP | Ref. allele | Other allele | Gene | Symptoms sub-group |
B | OR | 95% CI | p-value | Previous associations |
|---|---|---|---|---|---|---|---|---|---|
| rs10493596 | T | C | AK5 | SOI + TI | −0.82 | 0.45 | [0.3 to 0.8] | 0.004 | Morning chronotype [2] |
| rs10823607 | T | C | ADAMTS14 | SOI + TI | − 0.71 | 0.5 | [0.2 to 0.9] | 0.039 | Sleep duration [4] |
| rs113851554 | T | G | MEIS1 | SOI + MI | 0.4 | 1.5 | [1.1 to 2] | 0.007 | Insomnia symptoms [13] |
| SOI + MI + TI | 0.36 | 1.4 | [1.1 to 2] | 0.007 | |||||
| rs11706236 | G | A | CACNA2D3 | MI + TI | −0.33 | 0.7 | [0.5 to 0.9] | 0.009 | Caffeine related insomnia [3] |
| rs12471454 | T | C | SATB2 | TI | −0.26 | 0.8 | [0.6 to 1] | 0.029 | Insomnia [4] |
| rs12927162 | G | A | TOX3 | MI | −0.15 | 0.9 | [0.7 to 1] | 0.036 | Morning chronotype [2] |
| rs1823125 | G | A | PAX8 | MI | 0.16 | 1.2 | [1 to 1.4] | 0.033 | Sleep duration [23] |
| rs1940013 | T | C | OPCML | SOI | 0.19 | 1.2 | [1 to 1.5] | 0.037 | Usual bedtime [22] |
| rs2221285 | T | C | ESRRG | SOI + TI | −0.53 | 0.8 | [0.7 to 1] | 0.027 | Sleep duration [23] |
| rs2287838 | G | A | PIN1 | SOI | −0.22 | 0.8 | [0.7 to 1] | 0.022 | Sleep duration [23] |
| rs2302729 | T | C | CACNA1C | SOI + TI | 0.64 | 1.9 | [1.2 to 3] | 0.009 | Sleep latency [4] |
| rs34714364 | T | G | APH1A | MI | 0.16 | 1.18 | [1 to 1.4] | 0.041 | Morning chronotype [2] |
| rs55694368 | T | G | PER2 | MI | −0.19 | 0.83 | [0.7 to 1] | 0.043 | Morning chronotype [2] |
| rs6437122 | G | C | UPP2 | SOI + MI + TI | −0.34 | 0.7 | [0.5 to 0.9] | 0.015 | Sleep duration [23] |
| rs9517132 | T | C | RANBP5 | SOI | −0.22 | 0.8 | [0.7 to 1] | 0.018 | Usual sleep duration [23] |
| rs9804200 | C | T | EBF3 | MI + TI | −0.21 | 0.81 | [0.7 to 1] | 0.044 | Usual bedtime [4] |
SOI sleep onset insomnia, MI maintenance insomnia, TI terminal insomnia