Table 1.
Patient characteristics
| Characteristic | n | Bone Metastasis (%) | Lung Metastasis (%) | Liver Metastasis (%) | Brain Metastasis (%) | Other Metastasis sites (%) | Multiple Metastasis sites (%) | p |
|---|---|---|---|---|---|---|---|---|
| n | 18,322 | 7292(39.80) | 2005(10.94) | 1346(7.34) | 276(1.51) | 1344(7.34) | 6059(33.07) | |
| Age (years, mean ± SD) | 62.34 ± 14.4 | 62.47 ± 14.2 | 66.24 ± 14.9 | 59.01 ± 15.1 | 61.15 ± 14.1 | 64.34 ± 14.5 | 61.25 ± 13.8 | < 0.001 |
| Year of diagnosis | ||||||||
| 2010 | 2819 | 1089(14.93) | 290(14.46) | 219(16.27) | 50(18.12) | 293(21.80) | 878(14.49) | < 0.001 |
| 2011 | 2938 | 1144(15.69) | 309(15.39) | 221(16.42) | 40(14.49) | 245(18.23) | 979(16.16) | |
| 2012 | 3004 | 1214(16.64) | 337(16.83) | 214(15.90) | 48(17.39) | 218(16.22) | 973(16.06) | |
| 2013 | 3201 | 1268(17.39) | 332(16.56) | 263(19.54) | 36(13.04) | 195(14.51) | 1107(18.27) | |
| 2014 | 3223 | 1261(17.29) | 355(17.71) | 230(17.09) | 53(19.20) | 215(16.00) | 1109(18.30) | |
| 2015 | 3137 | 1316(18.05) | 382(19.05) | 199(14.78) | 49(17.75) | 178(13.24) | 1013(16.72) | |
| Race | ||||||||
| White | 13,810 | 5735(78.65) | 1410(70.37) | 997(74.04) | 193(69.93) | 1010(75.17) | 4465(73.69) | < 0.001 |
| Black | 3108 | 1055(14.47) | 422(21.02) | 246(18.32) | 65(23.55) | 232(17.25) | 1088(17.95) | |
| Others | 1338 | 475(6.51) | 166(8.27) | 101(7.49) | 18(6.52) | 93(6.91) | 485(8.01) | |
| Unknown | 66 | 27(0.37) | 7(0.35) | 2(0.15) | 0(0.00) | 9(0.67) | 21(0.35) | |
| Marital status | ||||||||
| Married | 7745 | 3208(43.99) | 748(37.30) | 615(45.62) | 96(34.78) | 602(44.76) | 2476(40.85) | < 0.001 |
| Unmarried | 9555 | 3719(51.01) | 1150(57.32) | 649(48.29) | 163(59.06) | 658(49.00) | 3216(53.08) | |
| Unknown | 1022 | 365(5.00) | 107(5.38) | 82(6.08) | 17(6.16) | 84(6.25) | 367(6.07) | |
| Grade | ||||||||
| I | 1189 | 679(9.31) | 89(4.43) | 47(3.49) | 10(3.62) | 96(7.14) | 268(4.42) | < 0.001 |
| II | 5816 | 2702(37.05) | 489(24.35) | 364(27.00) | 48(17.39) | 351(26.10) | 1862(30.71) | |
| III & IV | 6514 | 2043(28.01) | 946(47.16) | 654(48.66) | 117(42.39) | 459(34.13) | 2295(37.88) | |
| Unknown | 4803 | 1868(25.63) | 481(24.05) | 281(20.85) | 101(36.59) | 438(32.64) | 1634(27.00) | |
| BC Subtype | ||||||||
| HR+/HER2- | 9538 | 4697(64.40) | 776(38.65) | 449(33.36) | 78(28.26) | 681(50.63) | 2857(47.15) | < 0.001 |
| HR+/HER2+ | 2497 | 858(11.76) | 249(12.40) | 287(21.32) | 36(13.04) | 112(8.33) | 955(15.76) | |
| HR−/HER2+ | 1309 | 236(3.24) | 197(9.81) | 238(17.68) | 25(9.06) | 79(5.87) | 534(8.81) | |
| Triple negative | 2067 | 479(6.57) | 426(21.22) | 194(14.42) | 72(26.09) | 183(13.61) | 713(11.77) | |
| Unknown | 2911 | 1022(14.03) | 357(17.93) | 178(13.22) | 65(23.55) | 289(21.56) | 1000(16.50) | |
| Stage T | ||||||||
| T0 | 432 | 196(2.69) | 31(1.54) | 26(1.93) | 13(4.71) | 63(4.68) | 103(1.70) | < 0.001 |
| T1 | 2156 | 971(13.33) | 199(9.91) | 187(13.87) | 33(11.96) | 179(13.31) | 587(9.68) | |
| T2 | 4867 | 2179(29.88) | 482(24.00) | 454(33.75) | 71(25.72) | 300(22.38) | 1381(22.77) | |
| T3 | 2584 | 1089(14.93) | 327(16.28) | 218(16.17) | 25(9.06) | 135(10.04) | 790(13.06) | |
| T4 | 5222 | 1678(23.01) | 689(34.41) | 274(20.33) | 70(25.36) | 390(29.00) | 2121(35.01) | |
| Tx | 3061 | 1179(16.17) | 277(13.84) | 188(13.95) | 64(23.19) | 277(20.59) | 1077(17.78) | |
| Stage N | ||||||||
| N0 | 4334 | 1987(27.25) | 456(22.71) | 338(25.15) | 64(23.19) | 369(27.43) | 1120(18.49) | < 0.001 |
| N1 | 5931 | 2508(34.40) | 597(29.73) | 519(38.58) | 83(30.07) | 377(28.10) | 1847(30.47) | |
| N2 | 1495 | 672(9.21) | 161(8.07) | 127(9.42) | 22(7.97) | 116(8.62) | 397(6.55) | |
| N3 | 4691 | 1416(19.42) | 591(29.48) | 253(18.77) | 67(24.28) | 309(22.97) | 2055(33.94) | |
| Nx | 1871 | 709(9.72) | 200(10.01) | 109(8.09) | 40(14.49) | 173(12.86) | 640(10.55) | |
| Surgery | ||||||||
| Yes | 4964 | 2266(31.07) | 673(33.52) | 495(36.72) | 73(26.45) | 464(34.50) | 993(16.38) | < 0.001 |
| No | 13,016 | 4874(66.83) | 1286(64.04) | 814(60.39) | 201(72.83) | 853(63.42) | 4988(82.26) | |
| Unknown | 342 | 152(2.10) | 46(2.44) | 37(2.89) | 2(0.72) | 27(2.08) | 78(1.37) | |
| Radiotherapy | ||||||||
| Yes | 5478 | 2622(35.95) | 313(15.59) | 185(13.72) | 162(58.70) | 288(21.41) | 1908(31.46) | < 0.001 |
| No | 12,497 | 4509(61.84) | 1645(82.07) | 1122(83.38) | 112(40.58) | 1023(76.13) | 4086(67.46) | |
| Unknown | 347 | 161(2.21) | 47(2.34) | 39(2.89) | 2(0.72) | 33(2.45) | 65(1.07) | |
| Chemotherapy | ||||||||
| Yes | 9176 | 3229(44.28) | 1039(51.74) | 888(65.88) | 136(49.28) | 632(46.99) | 3252(53.63) | < 0.001 |
| No/Unknown | 9146 | 4063(55.72) | 966(48.26) | 458(34.12) | 140(50.72) | 712(53.01) | 2807(46.37) | |
Abbreviations: BC breast cancer, HR hormone receptor, HER2 human epidermal growth receptor 2, TN triple negative