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. 2019 Nov 12;11:94. doi: 10.1186/s13098-019-0491-1

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Ballooning degeneration and fatty change of hepatocytes in Zucker rats. Liver tissues were collected after 6-month treatment with vehicle or metformin. PAS staining demonstrated patch-distributed ballooning degeneration and fatty change of hepatocytes in vehicle- and metformin-treated ZDF rats