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. 2019 Nov 12;11:94. doi: 10.1186/s13098-019-0491-1

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Immunofluorescence microscopy of cytochrome c oxidase (CCO). Liver tissues obtained after 6-month treatment with vehicle or metformin were stained with anti-CCO (green). The CCO staining was weak and uniform in Zucker lean rats, whereas Zucker diabetic fatty rats showed patched of strong CCO reactivity. Stronger CCO labeling was seen at the intracellular vacuoles in hepatocytes with ballooning degeneration from metformin-treated rats (ZDF + metformin-1, (ZDF + metformin-2)