Table 1.

Take home messages

- Know that anti-TNF drugs are the first cause of drug-induced lupus. - Do a reference assay of ANA and anti-DNA before starting an anti-TNF. - Do not monitor these rates in the absence of clinical signs. - The presence of ANA before treatment does not contraindicate treatment. - Evoke induced lupus in front of a compatible chronology plus clinical signs and autoantibodies. - Do not diagnose induced lupus on isolated skin damage in an autoimmune context: a “simple” rash or arthralgia with anti-DNA is not sufficient for diagnosis. - Always think about looking for visceral signs. - Stop the product in case of induced lupus and do not take another anti-TNF agent but change class.