Table 4.
Genotype and allele frequencies for the MTHFR C677T polymorphism and DNA methylation in EPL cases, ESCC cases and healthy controls
| Variables | Control n (%) |
EPL | ESCC | ||||
|---|---|---|---|---|---|---|---|
| n (%) | OR (95% CI) | p value | n (%) | OR (95% CI) | p value | ||
| MTHFR C677T | |||||||
| CC | 99 (49.5) | 85 (42.5) | 1.00 | 84 (42.0) | 1.00 | ||
| CT | 82 (41.0) | 80 (40.0) | 1.14 (0.74–1.73) | 0.55 | 97 (48.5) | 1.39 (0.92–2.11) | 0.12 |
| TT | 19 (9.5) | 35 (17.5) | 2.15 (1.14–4.03) | 0.02 | 19 (9.5) | 1.18 (0.59–2.37) | 0.65 |
| C | 280 (70.0) | 250 (62.5) | 1.00 | 265 (66.3) | 1.00 | ||
| T | 120 (30.0) | 150 (37.5) | 1.40 (1.04–1.89) | 0.03 | 135 (33.8) | 1.19 (0.88–1.60) | 0.26 |
| DNA methylation | |||||||
| p16 methylation | 70 (35.0) | 92 (46.0) | 1.58 (1.06–2.37) | 0.03 | 126 (63.0) | 3.16 (2.10–4.76) | < 0.01 |
| p53 methylation | 74 (36.5) | 84 (42.0) | 1.23 (0.83–1.84) | 0.36 | 113 (56.5) | 2.21 (1.48–3.30) | < 0.01 |