Fig. 1.

Salinomycin counteracts the proliferation of uveal melanoma cells. a Chemical structure of salinomycin. b Uveal melanoma (UM) cells and ARPE-19 cells were treated with a gradient concentrations of salinomycin for 72 h, and the cell viability was measured by MTS assay. Data represent mean ± SD. *, P < 0.05; ***, P < 0.001, one-way ANOVA, post hoc comparisons, Tukey’s test. c After UM cells were treated with the indicated concentrations of salinomycin for 24 h, viable cells were seeded into drug-free agarose-containing culture for 14 days. Clonogenicity was expressed by normalizing to control in colony count. Data represent mean ± SD. ***, P < 0.001, one-way ANOVA, post hoc comparisons, Tukey’s test