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. 2019 Nov 13;18:159. doi: 10.1186/s12943-019-1068-1

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Salinomycin suppresses outgrowth of xenografted UM cells in NOD/SCID mice. a Tumor growth curve over time was plotted in the NOD/SCID mice injected (i.p.) with either vehicle (corn oil) or 2.5 mg/kg salinomycin daily. Data represent mean ± SD. ***, P < 0.001. Student’s t test. b Weights of tumors dissected on day 21 after administration with vehicle or salinomycin. Representative tumors are shown (left). Data (right) are the mean ± SD of tumor weights from each group. Vehicle (n = 8), salinomycin (n = 8). ***, P < 0.001. Student’s t test. c Hematoxylin & eosin (H&E) and immunohistochemistry (IHC) staining of Ki67, active caspase-3 and Twist1 in tumor tissue sections were conducted. Scale bar: 100 μm. d Protein levels of Twist1 from the tumors in NOD/SCID mice were analyzed with Western blot