Table 3.
Bisphenol A-induced changes on lipid peroxidation and enzymatic antioxidants in cauda epididymis of mice
| Sr. No. | Experimental group | LPO | Enzymatic Antioxidants | ||
|---|---|---|---|---|---|
| Catalase | SOD | GSH-Px | |||
| Control groups | |||||
| I | Untreated control | 1.462±0.11 | 2.066±0.05 | 6.725±0.31 | 0.407±0.03 |
| II | Vehicle control (0.2 ml olive oil /animal/day) | 1.470±0.09 | 2.022±0.05 | 6.707±0.28 | 0.402±0.02 |
| BPA-treated groups | |||||
| III | BPA-Low dose (80mg/kg bodyweight/day) | 2.092±0.12* (42.33) | 1.643±0.07* (18.75) | 5.648±0.18* (15.79) | 0.310±0.02* (22.90) |
| IV | BPA-Medium dose (120 mg/kg bodyweight/day) | 2.476±0.10* (68.43) | 1.309±0.05* (35.24) | 4.911±0.12* (26.78) | 0.259±0.01* (35.53) |
| V | BPA-High dose (240 mg/kg bodyweight/day) | 2.971±0.06* (102.14) | 1.111±0.12* (45.04) | 4.021±0.11* (40.05) | 0.209±0.02* (47.99) |
Values are mean±S.E.M., n=10, Values shown in parenthesis indicate: Brackets – Percent change in BPA-treated from vehicle control. Level of significance; ap <0.05 as compared to vehicle control, bp<0.05 as compared to BPA-HD -treated. No significant difference was noted between different control groups (Groups I-III). Units: LPO – nmoles MDA formed/mg protein/60 min; Catalase – μmoles H2O2 consumed/mg protein/min; SOD – units/mg protein; GSH-Px- nmoles of NADPH consumed/mg protein/min.