. 2019 Oct 18;11(3):221–235. doi: 10.2478/intox-2018-0021

Table 3.

Effect of Neurocalyx calycinus leaves ethanolic fraction on relative organ weights in sub-chronic oral toxicity study in Wistar rats.

^#Organs	Treatment group				Satellite group
^#Organs	Control	NCEF 50 mg/kg	NCEF 500 mg/kg	NCEF 1000 mg/kg	Control	NCEF 1000 mg/kg
Female
Liver	3.14 ± 0.13	3.05 ± 0.08^ns	2.96 ± 0.12^*	2.93 ± 0.15^**	3.02 ± 0.09	3.03 ± 0.14^ns
Kidney (L)	0.33 ± 0.01	0.32 ± 0.04^ns	0.32 ± 0.02^ns	0.34 ± 0.02^ns	0.32 ± 0.02	0.32 ± 0.02^ns
Kidney (R)	0.34 ± 0.02	0.29 ± 0.02^ns	0.32 ± 0.03^ns	0.35 ± 0.02^ns	0.31 ± 0.01	0.34 ± 0.01^ns
Lungs	0.55 ± 0.01	0.59 ± 0.02^ns	0.63 ± 0.06^ns	0.55 ± 0.04^ns	0.55 ± 0.02	0.54 ± 0.01^ns
Spleen	0.29 ± 0.04	0.32 ± 0.05^ns	0.37 ± 0.01^ns	0.31 ± 0.01^ns	0.35 ± 0.04	0.32 ± 0.04^ns
Heart	0.36 ± 0.01	0.34 ± 0.01^ns	0.36 ± 0.02^ns	0.34 ± 0.02^ns	0.33 ± 0.02	0.33 ± 0.01^ns
Brain	0.49 ± 0.01	0.55 ± 0.03^ns	0.53 ± 0.03^ns	0.52 ± 0.03^ns	0.4 ± 0.01	0.51 ± 0.03^ns
Ovary (L)	0.02 ± 0.01	0.02 ± 0.01^ns	0.02 ± 0.01^ns	0.02 ± 0.01^ns	0.02 ± 0.01	0.02 ± 0.01^ns
Ovary (R)	0.02 ± 0.01	0.02 ± 0.01^ns	0.02 ± 0.01^ns	0.02 ± 0.01^ns	0.02 ± 0.01	0.02 ± 0.01^ns
Male
Liver	2.86 ± 0.05	2.91 ± 0.16^ns	2.89 ± 0.11^ns	2.67 ± 0.08^**	2.82 ± 0.03	2.84 ± 0.14^ns
Kidney (L)	0.31 ± 0.02	0.30 ± 0.01^ns	0.32 ± 0.01^ns	0.32 ± 0.02^ns	0.30 ± 0.02	0.30 ± 0.01^ns
Kidney (R)	0.31 ± 0.02	0.32 ± 0.01^ns	0.33 ± 0.01^ns	0.35 ± 0.02^ns	0.32 ± 0.01	0.31 ± 0.02^ns
Lungs	0.50 ± 0.01	0.51 ± 0.02^ns	0.52 ± 0.02^ns	0.48 ± 0.01^ns	0.54 ± 0.05	0.47 ± 0.01^ns
Spleen	0.28 ± 0.02	0.29 ± 0.03^ns	0.23 ± 0.03^ns	0.29 ± 0.04^ns	0.27 ± 0.04	0.26 ± 0.03^ns
Heart	0.35 ± 0.02	0.33 ± 0.02^ns	0.34 ± 0.01^ns	0.36 ± 0.01^ns	0.33 ± 0.01	0.34 ± 0.01^ns
Brain	0.49 ± 0.03	0.49 ± 0.04^ns	0.46 ± 0.01^ns	0.46 ± 0.01^ns	0.44 ± 0.03	0.42 ± 0.02^ns
Testis (L)	0.35 ± 0.01	0.34 ± 0.01^ns	0.35 ± 0.02^ns	0.36 ± 0.01^ns	0.33 ± 0.01	0.34 ± 0.01^ns
Testis (R)	0.35 ± 0.01	0.35 ± 0.01^ns	0.34 ± 0.01^ns	0.35 ± 0.01^ns	0.32 ± 0.01	0.34 ± 0.01^ns

The values are expressed as Mean ± SEM, n=4. ^#g/100 g body weight. ns = non-significant, *p<0.05, **p<0.01 significantly different from the control group by using two-way ANOVA followed by Dunnett’s multiple comparison test. L, left; R, right.