Table 2.
MBBC and FBEC values for fosfomycin (FOS), ciprofloxacin (CIP), and gentamicin (GEN) in combination against E. coli and P. aeruginosa.
| Antibiotic | E. coli (ATCC 25922) | P. aeruginosa (ATCC 27853) | ||
|---|---|---|---|---|
| MBBC (μg/ml) | FBEC (interpretation) | MBBC (μg/ml) | FBEC (interpretation) | |
| FOS + CIP | 128 + 8 | 0.75 (NS) | 256 + 256 | 0.75* (NS) |
| FOS + GEN | 2 + 1 | 0.06 (S) | 256 + 2 | 0.38* (S) |
| GEN + CIP | 1 + 2 | 0.19 (S) | 4 + 8 | 0.26 (S) |
MBBC, minimal biofilm bactericidal concentration; FBEC, fractional biofilm eradication concentration; S, synergism, NS, no synergism; *MBBCFOS of P. aeruginosa was considered equal to 1,024 μg/ml for FBEC calculations.