Table 1.
Examples of PVT1-interacting microRNAs.
| Type of cancer | Effects of PVT1 silencing | MiRNA | Targets | References |
|---|---|---|---|---|
| Bladder cancer | ↓ Tumor growth | miR-31-5p | CDK1 | (70) |
| ↓ Tumor growth | miR-128-3p | VEGFC | (71) | |
| Cervical cancer | ↑ Cell apoptosis | miR-195-5p | SMAD3 | (72) |
| Colorectal cancer | ↓ Tumor growth | miR-455-5p | RUNX2 | (73) |
| ↓ Cell proliferation, invasion, and migration | miR-26b | - | (74) | |
| ESCC | ↓ Tumor growth | miR-203a-3p | LASP1 | (75) |
| Hepatocellular carcinoma | ↓ Tumor growth | miR-150-5p | HIG2 | (76) |
| - | miR-365-3p | ATG3 | (77) | |
| ↓ Cell proliferation and invasion | miR-186-5p | YAP1 | (78) | |
| HUVEC* | ↓ Cell migration | miR-26b-5p | ANGPT2 and CTGF | (79) |
| Gallbladder cancer | ↓ Cell proliferation and invasion | miR-143-3p | HK2 | (80) |
| Gastric cancer | - | miR-152-3p | CD151, FGF2 | (81) |
| - | miR-216a-5p | YBX1 | (82) | |
| ↓ Cell proliferation and migration | miR-186-5p | - | (83) | |
| Glioma | ↓ Tumor growth | miR-190a-5p | MEF2C | (84) |
| ↓ Tumor growth | miR-488-3p | |||
| ↓ Invasion and migration | miR-200a-3p | - | (85) | |
| ↓ Tumor growth | miR-128-3p | GREM1 | (86) | |
| ↓ Cell proliferation | miR-186-5p | - | (87) | |
| Lung cancer | ↓ Cell proliferation | miR-126-3p | SLC7A5 | (88) |
| LSCC | ↓ Cell proliferation and migration | miR-519d-3p | - | (89) |
| Melanoma | ↓ Cell proliferation | miR-26b-5p | - | (90) |
| NSCLC | ↓ Tumor growth | miR-195-5p | - | (91) |
| ↓ Tumor growth | miR-497-5p | - | (92) | |
| ↓ Cell proliferation | miR-200a-5p | MMP9 | (93) | |
| miR-200b-5p | ||||
| - | miR-216b | Beclin 1 | (94) | |
| ↓ Cell proliferation and invasion | miR-125b-5p | E2F2 | (40) | |
| Osteosarcoma | ↓ Tumor growth | miR-195-5p | - | (95) |
| ↑ Chemoresistance to gemcitabine | miR-152-3p | c-MET | (96) | |
| ↓ Cell proliferation | miR-497-5p | HK2 | (97) | |
| Ovarian cancer | ↓ Cell proliferation, invasion, and migration | miR-133a-3p | - | (98) |
| ↓ Cell proliferation | miR-140-5p | - | (99) | |
| Pancreatic cancer | - | miR-488-3p | - | (100) |
| ↓ Cell proliferation, invasion and migration | miR-448 | SERBP1 | (100) | |
| ↓ Tumor growth | miR-20a-5p | ULK1 | (101) | |
| PTC | ↓ Cell proliferation and invasion | miR-30a-5p | IGF1R | (102) |
| Prostate cancer | ↓ Cell proliferation and migration | miR-186-5p | Twist1 | (103) |
| Renal cell carcinoma | ↓ Cell proliferation and invasion | miR-16-5p | - | (104) |
| Retinoblastoma | ↓ Tumor growth | miR-488-3p | Notch2 | (105) |
ESCC, Esophageal squamous cell carcinoma; LSCC, Laryngeal squamous cell carcinoma; NSCLC, Non-small cell lung cancer; PTC, Papillary thyroid carcinoma; HUVEC, Human umbilical vein endothelial cells.
*
Indicates that experiments were performed in non-tumoral human cell lines.