Table 4. Top 20 small molecules of the differentially expressed genes.

Molecule in CTD	FDR	Gene count	Target gene
Palbociclib	9.49E-25	27	CDKN3, PTTG1, CENPF, PBK, OIP5, et al.
Dasatinib	1.52E-19	33	CDKN3, PTTG1, CENPF, PBK, ACTC1, et al.
Azathioprine	8.35E-19	36	CDKN3, NID2, CENPF, PBK, MCM2, et al.
2,3-bis(3′-hydroxybenzyl) butyrolactone	1.52E-18	42	THSD4, CDKN3, PTTG1, CENPF, PBK, et al.
Troglitazone	1.21E-16	46	CDKN3, NID2, PTTG1, ANGPT2, CENPF, et al.
Vinylidene chloride	1.83E-16	48	ENTPD7, CDKN3, NID2, PHLDA1, et al.
Zoledronic acid	4.37E-15	46	CDKN3, NID2, CENPF, PBK, ACTG2, et al.
Trimellitic anhydride	4.78E-15	52	CDKN3, PTTG1, POC1A, SLC25A4, PBK, et al.
Amphotericin B, deoxycholate drug combination	6.20E-15	26	CENPF, SPP1, MCM2, NFKBIZ, MCM4, et al.
Fluorouracil	6.33E-15	44	CDKN3, COL6A3, PTTG1, ANGPT2, ACTC1, et al.
Coumestrol	7.33E-15	50	THSD4, CDKN3, PTTG1, POC1A, CENPF, et al.
Lucanthone	9.66E-13	19	CDKN3, CENPF, PBK, HMMR, MCM10, et al.
1,4-bis(2-(3,5- dichloropyridyloxy)) benzene	7.68E-12	44	CDKN3, POC1A, REEP1, PHLDA1, CENPF, et al.
Mustard Gas	1.78E-11	39	CDKN3, PHLDA1, SPP1, PBK, MCM2, et al.
Polychlorinated Biphenyls	4.97E-11	27	CDKN3, CENPF, SPP1, PBK, MCM2, et al.
Ozone	1.56E-10	37	CDKN3, MYOM1, PHLDA1, CENPF, SPP1, et al.
2,4,5,2′,4′,5′- hexachlorobiphenyl	1.64E-10	44	COL6A3, PTTG1, CENPF, SPP1, TMEM158, et al.
benzo(b)fluoranthene	3.46E-10	40	THSD4, CDKN3, TMEM30B, PTTG1, REEP1, et al.
propionaldehyde	4.91E-10	45	NID2, PTTG1, POC1A, PHLDA1, CENPF, et al.
2,4,4′-trichlorobiphenyl	5.09E-10	38	COL6A3, PTTG1, CENPF, GNG13, PBK, et al.

CTD: comparative toxicogenomics database; FDR: false discovery rate.