Fig. 10.

The effects of BA mixtures after 24 h treatment following biliary transporter inhibition by MK571 (MRP inhibitor) and bosentan (BSEP inhibitor) on mitochondrial OCR in HepaRG cells. Mitochondrial parameters; (A) ATP-linked respiration, (B) Basal respiration, (C) Spare respiratory capacity and (D) Proton leak, were calculated from OCR data to allow in-depth analysis of mitochondria after BA treatment. All results were normalised to μg of protein per well. Data are presented as ± SEM of n = 3 experiments.