Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Nov 12;8(1):1642–1657. doi: 10.1080/22221751.2019.1686335

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 7. — Structural comparisons of the glycan binding sites between the GII.3 TV24 and the GII.11 VA34. (A and B) Top views of the surface structures VA34 (A) and TV24 (B) P dimers (surface model with two monomers coloured as grey and sand) with the indication of the proved HBGA binding sites (HBSs, green) of TV24 (B) and the corresponding location (green) of VA34 (A). Two major mutations, T/Q355 (cyan) and R/V451 (purple) at this region of VA34 (numbered based on GII.11 VA34, see Figure 4 for details) are shown. (C and D) Superimposition of the top surface structures of the TV24 (grey) and VA34 (orange) P dimers (C) with a closeup of the HBS locations in (D), highlighting the T355Q (cyan) and the R451 V (purple) mutations (numbered based on GII.11 VA34). The type A tetrasaccharides that bind TV24 are shown in a stick model with indication of the four sugars individually. The red arrow indicates the clash between the Q355 and the Fuc.