Figure 5. Anti-PS IgG antibodies show distinct correlations with classical and atypical MBC subsets in P. falciparum patients.
Correlation analysis of levels of (A) atypical and classical (B) MBCs with anti-PS IgG antibody levels from the plasma of P. falciparum patients. (C) Correlation analysis of atypical and classical MBC levels. Significance was assessed by non-parametric Spearman correlation analysis.
Figure 5—source data 1. Source data for Figure 5.
elife-48309-fig5-data1.zip (15.4KB, zip)
DOI: 10.7554/eLife.48309.035
Figure 5—figure supplement 1. Anti-PS IgG antibodies do not correlate with other B-cell subsets in P. falciparum patients.
Non-parametric Spearman Correlation analysis of (A) naïve B-cells (CD27–CD21+CD10–), (B) immature B-cells (CD10+), and (C) plasma cells (CD27+CD21–CD20–) with anti-PS IgG antibody levels from the plasma of P. falciparum patients.
Figure 5—figure supplement 1—source data 1. Source data for Figure 5—figure supplement 1.
elife-48309-fig5-figsupp1-data1.zip (13.9KB, zip)
DOI: 10.7554/eLife.48309.030
Figure 5—figure supplement 2. Correlations of anti-RBC IgG antibodies with B-cell subsets in P. falciparum patients.
Non-parametric Spearman Correlation analysis of (A) atypical MBCs (CD27–CD21–FcRL5+), (B) classical MBCs (CD27+CD21+), (C) naïve B-cells (CD27–CD21+CD10–), (D) immature B-cells (CD10+), and (E) plasma cells or plasmablasts (CD27+CD21–CD20–) with anti-erythrocyte lysate IgG antibody levels from the plasma of P. falciparum patients.
Figure 5—figure supplement 2—source data 1. Source data for Figure 5—figure supplement 2.
elife-48309-fig5-figsupp2-data1.zip (20.6KB, zip)
DOI: 10.7554/eLife.48309.032
Figure 5—figure supplement 3. Anti-DNA IgG antibodies do not correlate with the B-cell subsets analyzed in P. falciparum patients.
Non-parametric Spearman correlation of (A) atypical MBCs (CD27–CD21–FcRL5+), (B) classical MBCs (CD27+CD21+), (C) naïve B-cells (CD27–CD21+CD10–), (D) immature B-cells (CD10+), and (E) plasma cells or plasmablasts (CD27+CD21–CD20–) with anti-DNA lysate IgG antibody levels from the plasma of P. falciparum patients.
Figure 5—figure supplement 3—source data 1. Source data for Figure 5—figure supplement 3.
elife-48309-fig5-figsupp3-data1.zip (17KB, zip)
DOI: 10.7554/eLife.48309.034