Table 1.
Trends in Biochemical, Sperm, and Sonographic Characteristics in a 28-Y-Old Man With Classic Salt-Wasting 21-Hydroxylase Deficiency and Testicular Adrenal Test Tumors
| Patient Variable | Baseline | Follow-Up at 5 Mo | Follow-Up at 24 Mo |
|---|---|---|---|
| Medication | Prednisone 5 mg daily | Dexamethasone 250 μg daily | Prednisone 3/3 mg twice daily |
| Fludrocortisone 50/50 μg twice daily | Fludrocortisone 50/50 μg twice daily | Fludrocortisone 100/50 μg twice daily | |
| 17-hydroxyprogesterone (13–120 ng/dL) | 13,060 | 66 | 160 |
| A4 (26–125 ng/dL) | 1025 | 16 | 30 |
| ACTH (5–46 pg/mL) | 866 | 13.5 | 45.1 |
| PRA (0.6–4.3 ng/mL/h) | 7.1 | 11 | 3.5 |
| FSH (1–11 U/L) | 1.7 | 5.4 | 4.3 |
| LH (1–8 U/L) | 1.3 | 1.0 | 3.0 |
| T (total) (240–950 ng/dL) | 473 | 287 | 355 |
| Dehydroepiandrosterone sulfate (0.80–5.60 μg/mL) | 0.50 | 0.23 | 0.27 |
| Estradiol (10–40 pg/mL) | 27.8 | 11.7 | N/A |
| A4/T ratio | 2.2 | 0.06 | 0.08 |
| Sperm count (>14 × 106/ mL) | 0 | 132 | 60 |
| % Motile sperm (>39%) | 0 | 35% | 50 |
| TART volume, mL | 5.01 | 0.47 | 0.59 |
| % Functional testicular volume | 84% | 99% | 99% |
| Weight, kg | 63.3 | 68.8 | 65.7 |