Table 1:

Characteristics of Unsuspected Invasive Neoplastic Lesions of the Ovary and Fallopian Tube Found On Pathological Examination Of 15 BRCA1 and BRCA2 Mutation Carriers Undergoing Prophylactic RRSO

Center	Patient	Age RRSO	BRCA1/2 Mutation	CA125	USS	Site of Lesion		Cytology	Path: 2–4mm	Complete Staging including nodes	Invasive stage	1ry Disease CXT	Cycles	Recurrence	Presentation	Site of Recurrence	DFI	Status	OS
						OV	FT
1	1	50	BRCA1	12	NR		√	negative	cuts No	Yes	2c	C/T	6	Yes	Routine CT	Liver metastases	34	DECEASED	57
	2	59	BRCA1	10	NR	√	√	negative	Yes	Yes	1c	C/T	6	0			86	DECEASED	86
	3	52	BRCA1	ND	3cm simple cyst	√		positive	Yes	Yes	3c	RT		0				NED	148
	4	48	BRCA1	ND	ND	√		negative	Yes	Yes	2c	C/T	3	Yes	Patient noted mass	Isolated groin mass	29	AWD	105
	5	43	BRCA1	54	2 cm cyst	√	√	positive	Yes	No	2c	C/T	6	0				NED	77
2	6	50	BRCA2	12	7cm L cyst1		√	negative	Yes	No	1a	C/T	3	0				NED	172
	7	53	BRCA2	7	NAD		√	negative	Yes	Yes	1a	C/T	6	0				NED	88
	8	52	BRCA1	9	NAD		√	positive	Yes	Yes	1c	C/T	6	0				NAD	101
	9	49	BRCA1	8	1.5 cm L 1.4 cm R cyst	√		negative	Yes	No	1a	NT		Yes	Serial Ca125 elevated	Omental deposits	83	AWD	143
	10	44	BRCA1	17	2.3 cm L cyst	√	√	positive	Yes	Yes	3c	C/T	6	0				NED	45
3	11	63	BRCA1	5	NAD		√	positive	Yes	No	1c2	C/T	6	Yes	Serial Ca125 elevated	Pelvis	17	DECEASED	150
	12	49	BRCA1	8503	NAD	√	√	positive	Yes	Yes	3c	C/T/LD	6	Yes	Serial Ca125 elevated	Unknown	31	DECEASED	121
	13	39	BRCA1	4	NAD		√	negative	Yes	No	1a	C/T	6	Yes	Bloating, early satiety, nausea	Peritoneal secondaries, positive nodes and ascites	47	AWD	71
	14	50	BRCA1	27	Questionable solid lesion L ovary	√		negative	Yes	Yes	1a	C/T	6	Yes	Serial Ca125 elevated	Isolated periaortic lymph node	24	NED	66
	15	39	BRCA1	15	ND		√	negative	Yes	Yes4	1a	C/T	3	0				NED	59

Key: RRSO risk reducing salpingo-oophorectomy NAD no abnormality detected NR no record ND not done CXT chemotherapy C carboplatin T taxane NT not treated DFI disease free interval [months] OS overall survival [months] AWD alive with disease NED no evidence of disease ND not done Path: Yes = entire fallopian tubes and ovaries submitted for 2–4 millimeter cross-sectional cuts of specimen, No: entire tubes were submitted but 8 slides were performed on left and 4 on right, with no note of microsectioning.

¹Neoplasia on opposite side from ultrasound finding

²Staged after 3 cycles of CXT

³CA125 result obtained day after RRSO

⁴Staged after 3 cycles of CXT