Table 1.

Pharmacokinetic Parameters of Cefiderocol Following Intravenous Infusions of Cefiderocol 2 g for 1 or 3 Hours in Healthy Subjects

	2000 mg as a 1-h Infusiona		2000 mg as a 3-h Infusiona
	Single Dose	Multiple Dosesb, Day 10	Single Dose
Parameter	(n = 6)	(n = 8)	(n = 43)
Cmax (μg/mL)	156 (7.9)	153 (12.9)	89.7 (20.5)
AUC0–∞ (μg × h/mL)	389.7 (9.0)	366.5 (14.0)	386.1 (17.2)
t1/2,z (h)	2.74 (10.2)	2.72 (21.6)	2.41 (14.0)

Source: Adapted from [27, 31].

Abbreviations: AUC_0–∞, area under the concentration–time curve extrapolated from time zero to infinity; C_max, maximum plasma concentration; t_1/2, terminal elimination half-life.

^aData are expressed as geometric mean (coefficient of variance % of geometric mean).

^bEvery 8 h, for 10 d.