Table 2.

Proposed Dose Regimens Based on Renal Function

Augmented renal function (CrCL ≥120 mL/min)	2 g every 6 h, 3-h infusion
Normal renal function (CrCL 90 to <120 mL/min)	2 g every 8 h, 3-h infusion
Mild renal impairment (CrCL 60 to <90 mL/min)	2 g every 8 h, 3-h infusion
Moderate renal impairment (CrCL 30 to <60 mL/min)	1.5 g every 8 h, 3-h infusion
Severe renal impairment (CrCL 15 to <30 mL/min)	1 g every 8 h, 3-h infusion
ESRD (CrCL <15 mL/min)	0.75 g every 12 h, 3-h infusion
Patient requiring intermittent hemodialysis	0.75 g every 12 h, 3-h infusiona
Patient with CVVH	1 g every 12 h, 3-h infusion
Patient with CVVHD or CVVHDF	1.5 g every 12 h, 3-h infusion

Source: Adapted from [35, 44].

Abbreviations: CrCL, creatinine clearance estimated by Cockcroft-Gault equation; CVVH, continuous venovenous hemofiltration; CVVHD, continuous venovenous hemodialysis; CVVHDF, continuous venovenous hemodiafiltration; ESRD, end-stage renal disease.

^aThe supplemental (third) dose of 0.75 g with 3-h infusion will be administered after the completion of intermittent hemodialysis on dialysis days.