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. Author manuscript; available in PMC: 2019 Nov 13.
Published in final edited form as: Nature. 2016 Oct 26;539(7629):452–455. doi: 10.1038/nature20149

Fig. 1. Many lncRNA and mRNA loci influence the expression of neighboring genes.

Fig. 1.

(a) Knocking out a promoter (black) could affect a neighboring gene (blue) directly (local) or indirectly (downstream). (b) Knockout of the linc1536 promoter. Left: genotypes. Right: allele-specific RNA expression for 129 and Castaneus (Cast) alleles normalized to 81 control clones (+/+). Error bars: 95% confidence interval (CI) for the mean (n ≥ 2 clones, see Table S1). (c) Gene neighborhoods oriented so each knocked-out gene (black) is transcribed in the positive direction. Blue neighboring genes show allele-specific changes in expression. ^see Note S3. (d) Average RNA expression on promoter knockout compared to wild-type alleles (n ≥ 2 alleles, see Table S1). *: FDR < 10%. ***: FDR < 0.1%.