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. Author manuscript; available in PMC: 2019 Nov 13.
Published in final edited form as: Nature. 2016 Oct 26;539(7629):452–455. doi: 10.1038/nature20149

Extended Data Fig. 4. Promoter knockouts for 5 intergenic lncRNAs affect the expression of a neighboring gene.

Extended Data Fig. 4.

Significance (z-score) of allele-specific expression ratios at all genes within 1 Mb of each of 5 lncRNA loci. Each dot represents a different heterozygous promoter knockout clone for a given gene. Dots are shown only for genes that are sufficiently highly expressed to assess allele-specific expression (see Methods). The y-axis is capped at –10 to +10 standard deviations from the mean. Black: knocked-out lncRNA. Blue: Gene with significant allele-specific change in gene expression (FDR < 10%). Independent clones are not expected to yield the same significance value (z-score), in part because read depth differs between samples.