Figure 5.

SOX2 overexpression drives migration and invasion that can be antagonized by WWC1. (A–B) Effect of SOX2 on cell migration (A) and invasion (B) of Eca109 cells assessed using Transwell assay. (C) Dose‐response curves of Eca109‐SOX2 and Eca109‐vector cells to cisplatin. (D–E) Effect of shSOX2 on cell migration (D) and invasion (E) of KYSE150 cells. (F‐G) KYSE150‐derived xenograft model was established in nude mice (n = 6 per group). Tumor volume was measured every other day (F), and tumor weights were measured at the end of the experiment (G). (H‐I) Effect of WWC1 on cell migration (H) and invasion (I) of Eca109‐SOX2 cells assessed using Transwell assay. *P < .05, **P < .01, ***P < .001