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. 2019 Feb 25;22(4):531–538. doi: 10.1038/s41391-019-0134-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a A patient with mCRPC who had progressed on abiraterone, sipuleucel-T, enzalutamide, and radium-223 was treated with trametinib, which induced a PSA response of 85% at three and 93% at five months. b Schematic of ongoing proof of concept Phase II clinical trial of trametinib for patients with mCRPC who have progressed on one or more prior therapies for mCRPC (NCT02881242). Correlative analyses aim to identify patients most likely to respond and suggest possible pathways of resistance