Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Nov 7;10:2619. doi: 10.3389/fimmu.2019.02619

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Csorba, Schirmbeck, Tuncer, Ribi, Roux-Lombard, Chizzolini, Huynh-Do, Vanhecke and Trendelenburg.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Specific humoral immune response and cross-reactivity in EBNA348 peptide-immunized C57BL/6N and C1qa^−/− mice. (A) In C1qa^−/− mice the EBNA348 peptide-specific immune response is associated with (B) measurable levels of cross-reacting anti-A08 IgG, n = 10. Immunized wild-type mice (C57BL/6N), have a specific anti- EBNA348 immune reaction (C), but no anti-A08 IgG were detected (D). (E) Levels of high-affinity anti-C1q antibodies in the sera (FB) of C1q^−/−mice, positive for anti-EBNA348 IgG and anti-A08 IgG, n = 6, p = 0.01, and in the sera (FB) of C57BL/6N mice, n = 8 (F). Animals of the control groups (n = 12 for C1q^−/− and n = 5 forC57BL/6N) had no IgG against any of the measured peptides or C1q. (G,H) Serum ANA levels in the sera (FB) of C1q^−/− and wild-type mice respectively, showed no significant difference between the EBNA348-immunized and the control groups. Data were plotted as median with IQR. PI, pre-immune; B1, 1st boost; B2, 2nd boost; B3, 3rd boost; FB, final bleed.