Figure 4.

Inhibition of neutrophil and monocyte recruitment mitigated cigarette smoke-induced exacerbation of ischemic brain injury. (A) Schematic diagram illustrates drug administration and experimental design. Mice received Bindarit (50 mg/kg, orally twice daily) at the indicated time points. MCAO mice receiving an equal volume of vehicle were used as controls. At day 1 after MCAO, neurodeficits and brain infarct volume were assessed. (B) TTC-stained brain sections from indicated groups of mice receiving exposure to cigarette smoke or normal air at 24 h after MCAO and reperfusion. (C) Bar graph shows brain infarct volume in indicated groups of mice. (D) Summarized mNSS in indicated groups of mice. n = 7 mice per group. Mean ± SD.