Figure 6.

Inhibition of NLRP3 inflammasome mitigated cigarette smoke-induced exacerbation of ischemic brain injury. (A) Schematic diagram illustrates drug administration and experimental design. Mice received MCC950 (10 mg/kg, i.p.) at indicated time points. Mice receiving an equal volume of vehicle were used as controls. At day 1 after MCAO, neurodeficits and brain infarct volume were assessed. (B) TTC-stained brain sections from indicated groups of mice receiving exposure to cigarette smoke or normal air at 24 h after MCAO and reperfusion. (C) Bar graph shows brain infarct volume in indicated groups of mice. (D) Summarized mNSS in indicated groups of mice. n = 7 mice per group. Mean ± SD.