. 2019 Nov 13;9:16710. doi: 10.1038/s41598-019-53037-0

Table 2.

Altered disease course of all published rNiV_M ferret cohorts.

Ferret cohort	Days p.i. to death	Fatality rate	Respiratory signs	Neurological signs	Reference
rNiV_M-wt	6-8	100%	+++	+	^‡,§
rNiV_M-V^ko	*	0%	−	−	²⁰
rNiV_M-W^ko	8-11	100%	++	++	²⁰
rNiV_M-C^ko	8	100%	++	++	²¹
rNiV_M-C^koW^ko	10-15^†	60%	+	++/+++□	²¹
rNiV_M-P_Y116E	8-9	100%	++	++	^‡
rNiV_M-P_Δ116-135	11-12	100%	+	+++	^‡

The absence (−) or presence of minor (+), moderate (++), or severe (+++) clinical signs of disease.

^*All of these animals survived.

^†Some of these animals survived, this indicates time to death for those that succumbed.

^‡Data from the current study.

^§Similar results to other rNiV_M-wt infected ferrets in refs^20,21.

One of five animals had minor, temporary neurological signs.

^□The two animals that survived only demonstrated moderate neurological signs while those that succumbed demonstrated severe neurological signs.