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. 2019 Nov 13;9:16680. doi: 10.1038/s41598-019-53209-y

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© The Author(s) 2019, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Probability of maintaining therapy free responses (TFR) upon TPO-RA discontinuation. Kaplan-Meier plot showing the estimated probability of TFR in patients who discontinue TPO-RA for reasons other than lack of efficacy and being followed for a minimum of 6 months (n = 41). Patients who died while on TPO-RA therapy were not included in the study. Solid black line represents patients that received only romiplostim (n = 23); solid grey line represents patients that received only eltrombopag (n = 12), and dashed black line represents patients that switched TPO-RA (n = 6). The number of patients that discontinue TPO therapy (“at risk”) and the cumulative loss of TFR events at time points are presented for each group below the figure.